Spark Science sits down with Behavioral Pharmacologist and WWU professor Dr. Jeff Grimm.
We talk about his background, new theories on addiction, rat parks and how sugar can be an addictive substance.
You can view the Kurzgesagt video on addiction by clicking on the link below
https://www.youtube.com/watch?v=ao8L-0nSYzg
Read the transcript of the Behavioral Neuroscience: Addiction podcast.
Click Here for Transcript
>> Here we go!
[“Chemical Calisthenics” by Blackalicious ]
♪ Neutron, proton, mass effect, lyrical oxidation, you’re irrelevant ♪
♪ Mass spectrograph, your electronvolt, atomic energy erupting ♪
♪ As I get all open on betatrons, gamma rays thermo cracking ♪
♪ Cyclotron any and every mic you’re on ♪
♪ Trans iridium, if you’re always uranium ♪
♪ Molecules, spontaneous combustion, pow ♪
♪ Law of definite proportion, gaining weight ♪
♪ I’m every element around ♪
>> Dr. Regina Barber DeGraaff: Welcome to Spark Science where we explore stories of human curiosity. I’m Regina Barber DeGraaff, Astrophysicist and Packman Master. I’m here with my cohost, improve specialist and butcher, Jordan Baker. And today we’re going to talk about addiction and neuroscience with Dr. Jeff Grimm. Welcome to the show.
>> Dr. Jeff Grimm: Thanks for having me.
>> Regina Barber DeGraaff: We’re going to talk now about addiction and what is your specialty, real quick, before we get into like –?
>> Dr. Jeff Grimm: Before we really get into it?
>> Regina Barber DeGraaff: Really get into it. Like a short —
>> Dr. Jeff Grimm: I would say my specialty is a non-complete specialty. I kind of think of myself as a behavioral pharmacologist and my interests are mostly in motivated behavior, but, as we’re talking about addiction today, that’s really what’s driven me and my research is focusing on that particular problem.
>> Regina Barber DeGraaff: So we have talked in the past, but we’re going to go back into the way-back machine, the time machine, and we’re going to talk about why you started into the field that you’re in today.
>> Dr. Jeff Grimm: OK.
>> Regina Barber DeGraaff: OK [laughing].
>> Dr. Jeff Grimm: That was —
>> Jordan Baker: Caught him off guard.
>> Dr. Jeff Grimm: That’s one of those questions.
>> Regina Barber DeGraaff: Yeah. Why are you a behavioral neuroscientist right now?
>> Dr. Jeff Grimm: OK. Good. So starting kind of with the bigger picture. I’ve always been interested in science. I think I was kind of coaxed that way, you know, parents are like, “Hey.” And I had one teacher I remember — not to pin it all on one person — but I think it was maybe 6th grade or something, just a really effective biology teacher, somebody who was really interested in trying to make things come to life for the kids.
So he did some quirky things like he came across a raccoon one day that had been run over.
>> Jordan Baker: Came across a raccoon.
>> Dr. Jeff Grimm: A crash.
>> Regina Barber DeGraaff: Made friends with him.
>> Jordan Baker: Right [laughing]. Gave him a biscuit in the morning.
>> Dr. Jeff Grimm: He told us that it was an accident. So I don’t know. But anyways he showed up with a dead raccoon. And that turned into an opportunity. So let’s dissect this raccoon. And we’re like, “Yeah.”
But he did like the — like all the organs like he would take out. And then he had — this is all coming back to me now — like the heart and then I remember he had the lungs. This sounds really just kind of — maybe I dreamt all this.
>> Regina Barber DeGraaff: It’s a memory of a memory.
>> Jordan Baker: He got down and he gave a little CPR so you could see the lungs working [laughing].
>> Dr. Jeff Grimm: Yeah.
>> Jordan Baker: Did he?
>> Dr. Jeff Grimm: With a straw. That’s the thing. I remember he had like a straw.
>> Regina Barber DeGraaff: I mean, he was sanitary [laughing]. With this road kill [laughing].
>> Dr. Jeff Grimm: And then he like eventually — so this was like over days so I’m assuming he kept it in a fridge like over night. But got into like boiling down to the bones and all that so we could look at the structure and all that.
He was one of those science teachers that went up for a competition to try to do the space shuttle.
>> Regina Barber DeGraaff: Oh, the Challenger.
>> Dr. Jeff Grimm: Yeah. So that — that shows you how old I am, I guess.
>> Regina Barber DeGraaff: No. No. But he did not get on?
>> Dr. Jeff Grimm: He didn’t make the however many cuts to get into that — that close into it. But he was one of those people, well respected.
>> Jordan Baker: OK. That was a pun.
>> Dr. Jeff Grimm: Yeah. Oh, you’re right.
>> Regina Barber DeGraaff: Autopsy. Good one [laughing].
>> Dr. Jeff Grimm: Sort of had like a big pot boiling.
>> Regina Barber DeGraaff: He’s boiling the animal.
>> Jordan Baker: The dead raccoon and it’s got its arms out like it’s in a Jacuzzi tub. Yeah.
>> Regina Barber DeGraaff: How did he get the kids to like not be repulsed by boiling a dead animal?
>> Dr. Jeff Grimm: That I’d have to go back and watch the video, which doesn’t exist.
>> Regina Barber DeGraaff: The video in your memory.
>> Dr. Jeff Grimm: Yeah. I don’t remember being that — it was gross, but not so gross. I think he helped just kind of make it like, “Hey, this is interesting.” And he did the thing like when — with the telescope and the sunspots and all, you know, you can look and not burn your eyes out and all that kind of good stuff. Just little memories like that.
So and then, in high school, a couple good biology teachers. I knew like when I went to college I was going to do something probably with biology and maybe with that kind of history of physicians, stuff in the family, maybe med school or something. My dad, he’s retired as an orthodontist. Actually, there’s a lot of physics in orthodontics. And I didn’t really know that at the time. I know that now.
>> Regina Barber DeGraaff: Wow. OK. Tell me — tell me about the physics in orthodontics.
>> Dr. Jeff Grimm: Well, just for moving stuff around.
>> Regina Barber DeGraaff: That’s true.
>> Dr. Jeff Grimm: Like force and all this — we should have him come on and talk about — he loves to talk about it. But I didn’t really think about it then, but now I kind of think, “Yeah. There’s a lot of that,” and watching him when he’d think like, “How am I going to fix this kid’s mouth. And I got to move this and then put enough torsion,” and all that kind of stuff.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: Over the next couple years I figured I really liked research. And that was, again, working with professors. I ended up having a really good mentor at the college I went to.
>> Regina Barber DeGraaff: Which was?
>> Dr. Jeff Grimm: Which was Whitman College.
>> Regina Barber DeGraaff: So this mentor is like at Walla Wall — sorry, at Whitman, in Walla Walla, and what does he or she do for you that really –?
>> Dr. Jeff Grimm: So she was new when I was new. And sometimes that’s kind of an interesting situation. I actually had that later in graduate school, kind of a new person that had just been hired. So backing up back to Whitman, so she was new, looking to have students come and work with her and her research. I was like, “OK. Let’s hear about what you do.”
And she was working with caterpillars at the time.
>> Regina Barber DeGraaff: Awesome. Oh, that’s right. You were telling us about — yeah.
>> Dr. Jeff Grimm: These creepy caterpillar. And they’re actually quite like pretty in a sense. Like they’re the tobacco hornworm.
>> Jordan Baker: Sounds pretty.
>> Dr. Jeff Grimm: Yeah. Manduca sexta.
>> Regina Barber DeGraaff: OK.
>> Dr. Jeff Grimm: For the sciency caterpillar types [laughing].
>> Jordan Baker: Nerds out there.
>> Dr. Jeff Grimm: But they’re a bright green, like this kind of almost like neon green. They do have like a horn that I think it’s more to destruct the birds because it’s on the back end and the birds I think it’s the — I don’t know, so then they can run away while the bird’s going after the horn. That’s what the — she was saying in the lit.
But, anyways, what we were looking at was more of a protein involved in molting. So, when they have the cocoon and then they need to break out, this one hormone starts that process. So she was interested in, if you learn more about that protein, you could learn more about ways to like shut it down so then maybe you could inhibit the ability of these caterpillar to turn into the hornworm, the mouth.
>> Regina Barber DeGraaff: Which was invasive.
>> Dr. Jeff Grimm: Well, it’s a problem with tobacco, which is a problem if you’re a tobacco farmer.
>> Jordan Baker: Probably shouldn’t have named it after a tobacco plant [laughing].
>> Regina Barber DeGraaff: Well, and —
>> Dr. Jeff Grimm: It’s also related — tobacco plants are related to like tomatoes and stuff like that. So there’s —
>> Regina Barber DeGraaff: Right. We were talking about that and how, in the Simpsons, there’s that episode where they cross breed the tomato and the tobacco and they call it “tomacco.” I always thought that was the most ridiculous thing ever until I started talking to you and you’re like, “Actually, they’re similar.”
>> Dr. Jeff Grimm: There’s some relationship there. Yeah. But so the cool thing about the lab is we got to take the tobacco hornworm, put him in a blender, you know, just like a normal blender, and then you whip it up and it’s like this green, frothy shake. Again, really neon green.
And that was where we started with the process of extracting this one protein. Yeah. It’s kind of like, you know, a shake you’d get at the co-op or something.
>> Jordan Baker: Like an Odwalla Super Food.
>> Dr. Jeff Grimm: A lot of protein.
>> Regina Barber DeGraaff: Was there accidents? Of people getting confused?
>> Dr. Jeff Grimm: “Oh, sorry. I drank your Odwalla.”
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: No.
>> Regina Barber DeGraaff: It was too neon for that?
>> Dr. Jeff Grimm: Yeah. It was like creepy neon. But stuff like that and she really let me, you know, work independently. She’d show me how to like run the protein gel, but she wasn’t like standing over there like da-da-da. It was, “Figure things out, trial, error, screw things up, sure.” And that was OK.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: That was a good start.
>> Regina Barber DeGraaff: She sounds great.
>> Dr. Jeff Grimm: Yeah.
>> Regina Barber DeGraaff: Is she still there?
>> Dr. Jeff Grimm: She’s still there.
>> Regina Barber DeGraaff: Wow. Do you remember her name?
>> Jordan Baker: You want to name drop her?
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: Dr. Kendra Golden.
>> Regina Barber DeGraaff: Oh, OK.
>> Dr. Jeff Grimm: Dr. Golden. She switched to study more bacteria stuff later on.
>> Regina Barber DeGraaff: So there’s no more green shakes?
>> Dr. Jeff Grimm: I don’t think so.
>> Regina Barber DeGraaff: OK. Maybe she’s working on something else that’s like purple.
>> Dr. Jeff Grimm: Yeah. Anything anyone can do on their free time.
>> Regina Barber DeGraaff: Really?
>> Dr. Jeff Grimm: At home. Why not?
>> Jordan Baker: Yeah.
>> Regina Barber DeGraaff: Oh, my gosh. I should tell my daughter this.
>> Dr. Jeff Grimm: Yeah.
>> Regina Barber DeGraaff: She’s very into like making potions.
>> Dr. Jeff Grimm: You’ll never use the blender again.
>> Regina Barber DeGraaff: Yeah. That’s fine.
[♪ Janelle Monae singing Wondaland ♪]
♪ La, la, la, la, la, la, la ♪
♪ La, la, la, la, la, la, la ♪
♪ Early late at night ♪
♪ I wander off into a land ♪
♪ You can go, but you mustn’t tell a soul ♪
>> Regina Barber DeGraaff: I want to bring you back to — so — kind of, you know, to tobacco and addiction. I think I can kind of see a connection, but that probably didn’t happen until grad school, right?
>> Jordan Baker: It wasn’t on purpose?
>> Dr. Jeff Grimm: No. I did not — no. Grad school, though, that’s where the drug stuff happened.
>> Regina Barber DeGraaff: Yeah. The drug stuff [laughing].
>> Jordan Baker: That’s usually where it does happen.
>> Regina Barber DeGraaff: College. College.
>> Dr. Jeff Grimm: Yeah, it’s usually college. So I went to grad school knowing that I wanted to study biology and behavior, kind of mix those two together. So I was a biology major, ground up the caterpillar, all that fun stuff. At the same time I found I was also interested in human behavior and I took I guess several courses in psychology. I ended up getting a minor. And I found that to be really interesting. Like the idea that, “Oh, we can try to figure out why people do what they do,” and social psychology was becoming like — it had been going pretty strong at that time, but it was becoming like really like people were talking about, “Hey, we can understand like bystander apathy and all — you know, why do people do these really stupid things?” and the role of the context and all that kind of stuff.
So I was like really interested in that, but I was also interested in biology.
>> Regina Barber DeGraaff: What era was this? Like what timeframe was this? I don’t mean to age you, but I’m thinking of the Seinfeld episode of bystander apathy, right? Where they get arrested for not helping out somebody who’s being like robbed.
>> Jordan Baker: Oh, yeah.
>> Dr. Jeff Grimm: Sure. So this would have been —
>> Regina Barber DeGraaff: Was it that time?
>> Dr. Jeff Grimm: This would have been before.
>> Regina Barber DeGraaff: OK.
>> Dr. Jeff Grimm: That.
>> Regina Barber DeGraaff: OK. Before that [laughing]. Got it.
>> Jordan Baker: Before 1998. Got it.
>> Dr. Jeff Grimm: Right [laughing].
>> Regina Barber DeGraaff: Well, it was like 1995.
>> Dr. Jeff Grimm: Yeah. So this was like late ’80s.
>> Regina Barber DeGraaff: OK. All right.
>> Dr. Jeff Grimm: But, yeah. But, you know, that’s still a question that comes up because it still happens.
>> Regina Barber DeGraaff: Yeah. It totally does.
>> Dr. Jeff Grimm: We have maybe a better understanding — I’m not a social psychologist, so I wouldn’t you know pretend to explain all that. But, yeah, I have a minor.
But it still — you know, it still happens. Just because we kind of have a better idea of how it happens doesn’t mean we can stop it from happening, unfortunately.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: So I was interested in that. I took one course in psychology that was actually a kind of interdisciplinary biology, psychology course. And like we have here at Western, it’s a class I teach, like behavioral neuroscience. It was called psychobiology — or it had a different name, but the same kind of idea. Like pushing those two things together like what’s going on in the brain related to behavior.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: So that’s where I ended college thinking that’s something I’d really want to study somehow. And there’s a lot of ways you can study that. I was actually kind of interested in epidemiology like, you know, human health. Like why do people — over time, why do some people end up sicker than other people and that kind of thing.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: But when I got to the problem at WSU — so I went to Pullman. You’ve been to Pullman, right?
>> Jordan Baker: Nope.
>> Dr. Jeff Grimm: Oh, my gosh.
>> Regina Barber DeGraaff: I got my PhD from WSU too.
>> Dr. Jeff Grimm: See?
>> Regina Barber DeGraaff: Go Cougs.
>> Dr. Jeff Grimm: I thought you guys were friends.
>> Regina Barber DeGraaff: He knows this [laughing]. He didn’t go there.
>> Dr. Jeff Grimm: You never visited while she was there.
>> Jordan Baker: No. I lived in California or Arizona.
>> Regina Barber DeGraaff: He was in California.
>> Dr. Jeff Grimm: OK.
>> Regina Barber DeGraaff: But — so I like where you’re going with this. So basically you’re looking into like why people do these things and like why — and we’re going to get to this video. So we’re going to take a quick break and our listeners and viewers will listen and watch this video by — I’m going to try to say this. I’ve been practicing a lot — Kurzgesagt.
>> Jordan Baker: You got it.
>> Regina Barber DeGraaff: Kurzgesagt.
>> Dr. Jeff Grimm: Gazuntite.
>> Regina Barber DeGraaff: And it’s a YouTube channel and Kurzgesagt, “in a nutshell,” in German. And they did this video on addiction and it’s an adaptation of Johann Hari’s New York Best Seller, Chasing the Scream: The First and Last Days of the War on Drugs.
So it’s a very short video, about three minutes long. And then we’ll talk about your actual research.
>> Dr. Jeff Grimm: OK. Sounds good.
>> What causes, say, heroin addiction? This is a really stupid question, right? It’s obvious. We all know it. Heroin causes heroin addiction. Here’s how it works.
If you use heroin for 20 days, by day 21, your body would physically crave the drug ferociously because there are chemical hooks in the drug. That’s what addiction means. But there’s a catch. Almost everything we think we know about addiction is wrong.
[♪♪♪]
If you, for example, break your hip, you’ll be taken to a hospital and you’ll be given loads of diamorphine for weeks or even months. Diamorphine is heroin. It’s in fact much stronger heroin than any addict can get on the street because it’s not contaminated by all the stuff that drug dealers dilute it with. There are people near you being given loads of deluxe heroin in hospitals right now. So at least some of them should become addicts, but this has been closely studied. It doesn’t happen.
Your grandmother wasn’t turned into a junky by her hip replacement. Why is that? Our current theory of addiction comes in part from a series of experiments that were carried out earlier in the 20th century. The experiment is simple. You take a rat and put it in a cage with two water bottles. One is just water. The other is water laced with heroin or cocaine. Almost every time you run this experiment, the rats will become obsessed with the drugged water and keep coming back for more and more until it kills itself.
But, in the 1970s, Bruce Alexander, a professor of psychology, noticed something odd about this experiment. The rat is put in the cage all alone. It has nothing to do but take the drugs. What would happen, he wondered, if we tried this differently? So he built Rat Park, which is basically heaven for rats. It’s a lush cage where the rats would have colored balls, tunnels to scamper down, plenty of friends to play with, and they could have loads of sex, everything a rat about town could wants. And they would have the drugged water and in the normal water bottles.
But here’s the fascinating thing. In Rat Park, rats hardly ever used the drugged water. None of them ever use it compulsively. None of them ever overdose. But maybe this is a quirk of rats, right?
Well, helpfully there was a human experiment along the same lines, the Vietnam War. Twenty percent of American troops in Vietnam were using a lot of heroin. People back home were really panicked because they thought there would be hundreds of thousands of junkies on the streets of the United States when the war was over. But a study followed the soldiers home and found something striking. They didn’t go to rehab. They didn’t even go into withdrawal. Ninety-five percent of them just stopped after they got home.
If you believe the old theory of addiction, that makes no sense. But, if you believe Professor Alexander’s theory, it makes perfect sense because, if you’re put into a horrific jungle in a foreign country where you don’t want to be and you could be forced to kill or die at any moment, doing heroin is a great way to spend your time. But, if you go back to your nice home with your friends and your family, it’s the equivalent of being taken out of that first cage and put into a human Rat Park.
It’s not the chemicals, it’s your cage. We need to think about addiction differently.
>> Jordan Baker: Welcome back to Spark Science where we’re talking about addiction with Dr. Jeff Grimm. So, in the video, it was 21 days for a heroin addict to become addicted to heroin. Was that when their body starts to crave it?
>> Dr. Jeff Grimm: Oh, the video I think is — it’s a nice introduction to some of the issues that are really important. So like what is the nature of addiction? That kind of thing. You know, what are possible solutions? But by itself — and probably because it’s so quick and it’s meant to be consumed, you know, by a general audience without having to get into too many of the details — there’s some oversimplification.
So I don’t know if there’s actually, you know, clinically speaking, like a particular number of exposures for somebody to become addicted to heroin. I’m sure it could be far less than 21 days.
>> Regina Barber DeGraaff: Right. I mean, how many times did you, you know — did you do the heroin in that 21 days?
>> Jordan Baker: Just once a day for 21 days?
>> Regina Barber DeGraaff: Right. Was it like 10 times a day?
>> Jordan Baker: Two or three times a day?
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: Right. And then the reason I say that is because addiction — I’m doing this thing again.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: Did you see the first one I did?
>> Regina Barber DeGraaff: Yeah, I did. Well, maybe we should take this time and like give a good definition of addiction. Because I don’t think they kind of do that. They just go right into addiction. They don’t say like, “Addiction is blah.” You know?
>> Dr. Jeff Grimm: Yeah. So what do you guys think it is?
>> Jordan Baker: I think it’s — it would be just like the — after the 21 days where your body becomes like — it needs it.
>> Dr. Jeff Grimm: So it needs it? OK.
>> Jordan Baker: Yeah. It’s sort of like a mental thing too sort of would force you to do certain things around your day that you’re like, “All right. I need my heroin around this time and this time,” or, “I need to start drinking by this time to feel normal.”
>> Regina Barber DeGraaff: Right. I had read that the other part of the definition was that addiction is — that causes you to do actions that are detrimental to your like wellbeing, to your life. So it was something like you would do things that were not productive like —
>> Jordan Baker: Sky diving?
>> Regina Barber DeGraaff: No [laughing]. That is detrimental.
>> Jordan Baker: Right.
>> Regina Barber DeGraaff: On average. My sister actually, you know, is a lawyer who like puts people in jail, which addiction is kind of a common theme. And so like if your addiction drives you to like, let’s say, steal, you know, or like borrow too much money and not pay it back, or like not go to pick up your kids or something like that, so things that are harmful to your life. That’s like in addition to what Jordan was saying about the medical part.
>> Dr. Jeff Grimm: Right. So you mentioned like a physical thing, physical addiction, which is — the term is typically “dependence.” So you literally become dependent, like your body — if you take the drug away, you get sick. So there are some drugs that have that particular outcome and heroin — the opiates, that’s a real classic example. Alcohol.
>> Regina Barber DeGraaff: I mean, caffeine to some extent. Like you go through the shakes.
>> Dr. Jeff Grimm: There’s a withdrawal associated with it. And so typically with some the withdrawal symptom is the sign that you were physically dependent. But that by itself does not mean you are addicted. And the video gets at that.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: It shows the people — like grandma, she wasn’t an addict just because she had her hip replacement. She had morphine.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: So you can go through the process of becoming dependent. You’re probably going to go through withdrawal assuming you had several doses of the drug. But, most likely, you’re not going to be like, “Oh, my God. I gotta have some more of that,” afterwards. Unless you’re still in a lot of pain.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: And that’s unfortunately what does happen to people and we could talk about like OxyContin and all the — you know, because there is a problem with people that can’t get off pain killers. But typically, I mean, if you’re monitored and — you’re probably not going to have a problem. You might, again, be dependent, go through withdrawal, you’re probably going to be good to go.
But then you were doing like, “Then there’s this mental stuff,” right?
>> Jordan Baker: Right.
>> Dr. Jeff Grimm: And you mentioned that as well.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: So you were saying like, “I got to find ways to get the drug. Like I’m thinking about it. I’m going to procure some more. I’ve got to find my dealer or whatever.” And then Regina was saying like, “I might do some stupid stuff in order to get it.” So that — really, the definition of addiction — actually the —
So if you’ve heard of the DSM, the Diagnostic and Statistics Manual.
>> Regina Barber DeGraaff: Only from you.
>> Jordan Baker: Yeah.
>> Dr. Jeff Grimm: Psychiatric Association. So if you’re a psychology major, you know, they all learn a bit about this as undergraduates and then, if they go in the clinical direction, then they — this becomes like this major resource they’re looking at all the time. And if you become a psychiatrist in medical school or nursing, all that kind of stuff, it’s this major thing when you want to diagnose somebody with some kind of psychiatric something.
>> Regina Barber DeGraaff: OK.
>> Dr. Jeff Grimm: So in there, just in the — just a few years ago, they changed some of their definition. It used to be a little bit more heavily dependent on definition having dependence as part frequency.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: But it — now it’s a little bit more nuanced and they actually don’t use the word “addiction.” They use “Substance use disorder.”
>> Regina Barber DeGraaff: OK.
>> Dr. Jeff Grimm: And then they have like specific details for alcohol and the opiates and things like that. But, overall, they had this big list and some of the things you were talking about are on there. Like dependence. You don’t have to be dependent to have a substance use disorder, but it is one of the criteria and like, out of this many, if you have a couple of these over — repeatedly over a 12 month period, you know, it kind of fits into the overall diagnosis.
But they also have that you experience a lot of distress. You may engage in behaviors that are detrimental to your health and safety, wellbeing, that kind of thing. So that’s the DSM.
Another definition that mirrors that, but the language is a little bit different — and this is for people if they’re interested. You could look up in the DSM online. You can also go to the National Institute on Drug Abuse website and they still use the word “addiction,” but it contains all those same elements. But the key things are essentially you’re preoccupied with getting the substance and you experience distress and you experience craving and you do basically kind of stupid things in order to get it.
And so it’s a lot of stuff. Really, from a psychology perspective, like all of those things — it’s not just this one, I’m addicted to morphine because I’m dependent on it.” It’s, Maybe I experience withdrawal when it’s taken away so them I’m like I don’t want to have that withdrawal so I want to take more of that drug.” So that could drive the drug taking. But I also experience a lot of anxiety and this kind of is a self-medication just in general. Maybe I was like that before I ever took morphine in the first place.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: So that kind of keeps me going. When I run into cues that remind me of when I used to take drugs.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: Just hypothetical — with my friends. Right? I run into those people or that place on write situation.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: Then I start craving and I’m going like — because craving for some people is like this real — it’s like when you’re really, really hungry.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: You know, that feeling where you’re like, “I got to have this,” and it becomes like this focus. And so I’m trying to understand that as a question.
And then the ability to hold back. Like if you experience all that stuff, like you used to have a lot of cocaine in the ’80s or something, right?
>> Regina Barber DeGraaff: People did that.
>> Dr. Jeff Grimm: Right. And then you quit and it’s all — you’re good to go. And then you go to some dinner party or something and they’re like, “Hey, we’ve got cocaine.”
>> Regina Barber DeGraaff: Right. I like how you’re like, “It has a lid,” and they’re like, “OK. here we go.”
>> Dr. Jeff Grimm: Like Thanksgiving.
>> Regina Barber DeGraaff: Like Thanksgiving [laughing].
>> Dr. Jeff Grimm: Yeah. And some $100 bills.
>> Regina Barber DeGraaff: These are not funny issues. I realize that. OK.
>> Dr. Jeff Grimm: Right. So you’re there like, “Ugh,” and you’re not dependent because — like if it’s cocaine, there’s not too much physical dependence that actually happens with cocaine.
>> Regina Barber DeGraaff: Really?
>> Dr. Jeff Grimm: But even if there was, it’s been years because we’re not in the ’80s anymore.
>> Regina Barber DeGraaff: Correct.
>> Dr. Jeff Grimm: But these memories come up and then you start craving so that you feel that, “Oh, my god. I remember what that –”
>> Regina Barber DeGraaff: Plus there’s the peer pressure of all the other people from the ’80s.
>> Dr. Jeff Grimm: Right. Maybe that’s the social context and they’re like, “Come on. You want to.” Right? But your ability to like say, “No,” that’s one other thing that happens with — some people are kind of on a spectrum. They’re kind of born on that side where they might have less ability to control their impulsive kinds of behaviors. But there’s a lot of evidence showing that once you’ve taken drugs for a period of time — and it’s not just cocaine, but heroin and other drugs — your ability — your brain changes so you have less ability to control your impulsive behavior.
So it’s like this huge mess of things for an addict. I’m using the word “addiction” because — actually I trained at night at National Institute on Drug Abuse so I’m kind of more using their language. But basically you’re set up, once you’ve had a lot of experience with drug abuse, become dependent or not, but, you know, you fit that category — those categories under the DSM or like NIDA’s definition. You’re basically set up to fail. Like when you’re in that situation, not only are you like being pulled towards it, but your ability to stop yourself. Like nobody’s holding you back and saying, “No.” I mean, you might be telling yourself, “no,” but that part of the brain’s just being like, “Shut up. Shut up. Shut up.” You just don’t have it.
[♪ Janelle Monae singing Wondaland ♪]
♪ Let me paint your canvas as you dance ♪
♪ Dance in the trees ♪
♪ Paint mysteries ♪
♪ The magnificent droid plays there ♪
>> Regina Barber DeGraaff: So you were mentioning, after we watched the video, that it is very simplistic, but also that that study that was mentioned isn’t always 100% true. Like you were saying not all the rats were super happy. Right? Didn’t you say that?
>> Dr. Jeff Grimm: Well, actually —
>> Regina Barber DeGraaff: Or didn’t even get addicted in the cages I think is what you said.
>> Dr. Jeff Grimm: Well, I look back at that paper — and I don’t want to diss on — so this was Dr. Alexander’s work. I’m sure he’s great. He’s written some books that a lot of people have really appreciated I think, especially, I’m guessing, addicts because it’s always nice I think for people to feel like, “Hey, somebody’s listening and trying to understand what I’m going through.”
So I think there’s some good stuff in there about social support, especially. But if you go back to the original papers, these are from the kind of mid, late 1970s, it’s pretty neat what he saw. But the video makes it — it just kind of dramatizes it a little bit. Remember that one part in the video? So the rat’s like — here’s the morphine. Here’s the water. And the morphine has the skull and cross bones — should have known.
>> Regina Barber DeGraaff: Right.
>> Jordan Baker: How could he not recognize the dangerous [laughing].
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: And it says something like, “Rats will consume to the point to they just die,” and it just dies or something like that.
>> Regina Barber DeGraaff: Are.
>> Dr. Jeff Grimm: And that’s the first part when I’m like, “Uh, actually,” and I don’t know if it’s because I’m so protective of rats as a species or something like that — it’s just not true. They’re not — they’re actually pretty smart. And overdose is actually not a typical situation. They are very good at — and this isn’t just rats, but other animals including humans for the most part are pretty good at titrating levels of drug intake to a level that is — I’ll use psychology terms — reinforcing. So it’s keeping you — like this is worth responding for this much.
But, if you go above that, there’s actually side effects kinds of things related to the drug that might make it harder for you to respond. Like you get too sleepy if it’s a sedating drug, or if it’s a drug like a psychostimulant, you’re just like over there like chewing your fingers or something.
So right in the — there’s a sweet spot. And the rats find that and — this is like my little graph — they just — they’ll stay at like — they won’t just go, “Ah,” and then die. And in that — one of those papers I was looking at, it does mention some of the rats died.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: And I was like, “What’s up with that?” They actually — the way I read it, they actually died like in the first few days with something about they got — they weren’t drinking enough water. It was like this weird little caveat in the methods section.
>> Regina Barber DeGraaff: It might have been dehydration as well.
>> Dr. Jeff Grimm: Dehydration and — because, in my experience working with animal models — because I work with rats — because we haven’t really talked about that yet — but I’ve worked a lot with rats self-administering cocaine and a little bit working with heroin. And it’s — again, it’s just really unlikely for them to just — you know, OD.
>> Regina Barber DeGraaff: They don’t overdose.
>> Dr. Jeff Grimm: There are certain kinds of situations. Like you can set up the context — some really interesting kind of situations.
>> Regina Barber DeGraaff: Tell us about that.
>> Dr. Jeff Grimm: With overdose. I haven’t worked with. But there’s an interesting set of papers, Shepherd Seagull is a psychologist is still doing work on this. It kind of was a little bit more esoteric I think at this point. But some of the early work was with rats trying to understand like why people overdose on heroin and about how the role of the context can become so important. And this is kind of — macabre.
>> Regina Barber DeGraaff: Which is what the video is talking about.
>> Dr. Jeff Grimm: Yeah. They’re — this is a little bit more like actual just conditioned. Like when you take — so this is kind of a side — I’ll keep this really quick. But you may have heard someone has overdosed on heroin. Right? Kind of like in our generation. I don’t know if you knew anybody from like high school. Like I knew — not in high school, but in the subsequent years. Like, “Oh, so and so died. They overdosed on heroin.”
>> Regina Barber DeGraaff: We come from Linden. They get in car accidents and it’s mostly car accidents.
>> Dr. Jeff Grimm: And corn farming.
>> Jordan Baker: And farm equipment.
>> Dr. Jeff Grimm: Yeah. Farm equipment.
>> Regina Barber DeGraaff: Yeah. It’s pretty sad actually, but — so like —
>> Dr. Jeff Grimm: So people say, “Oh, they overdosed.”
>> Regina Barber DeGraaff: Like — celebrity.
>> Dr. Jeff Grimm: And it was because they took too much. Yeah. They were — and with celebrities I’ve heard this. You know, “So and so overdosed on heroin,” and it’s like — maybe I kind of look and only see what I want to see. But have you ever heard that idea like they weren’t expecting to take the drug that day after the Oscars or whatever.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: And they hadn’t had the drug in a long time so they weren’t as tolerant. And so there’s just that physical level of tolerance that you don’t have. So then you take this big dose because, “When I used to take it, I used to take this big dose.”
>> Jordan Baker: Right.
>> Dr. Jeff Grimm: It’s kind of like if you haven’t been drinking alcohol in a long time and you go, “Ah, I used to drink, you know, a 12 pack,” or something and then you have like one pint or something and you’re like [snores] because you’re old and you have children.
>> Regina Barber DeGraaff: Right. That is true for all of us.
>> Dr. Jeff Grimm: Right. Not the 12 pack thing, but — so we you also can have — this can also happen with alcohol too. But with opiates, if you take the heroin — could also be with morphine — in the same context repeatedly, you can actually have conditions tolerance. So in that particular space with like those people or that — actually literally that particular room or something like that — you develop like an extra level of tolerance.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: That’s not there if you go into some other environment and take the same dose of the drug.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: So that whole conditioned tolerance kind of effect was studied initially with an end point with rats where they actually would die. And that’s typically not what — how they do their animal research these days. But it was kind of this surprising finding like, here’s these rats, this one and this one, they have the same experience of increasing doses of morphine over several days. They both have it in box A. But, on the test day, this guy now gets put in a box they’ve never been in before, gets the same dose as this guy that stays in the box he’s familiar with. This one dies.
>> Regina Barber DeGraaff: Wow.
>> Dr. Jeff Grimm: And so that’s where it was like, “Wow. Maybe that’s what happens with people.”
>> Regina Barber DeGraaff: Yeah. Well, it’s like that — what is it that old story that, you know, you hear about the — I don’t remember when I heard this — as a child — the story of the old man who is like the oldest man in the village or something like that and he gets invited to the king’s castle for a great big feast because it’s his birthday and he’s the oldest person like in that kingdom or whatever. And so the king gives him like this big feast. And this old man, you know, has been eating the same thing every day, you know, his whole life because he’s, you know, not a king. And then the day after he eats that meal, he like dies, right, because his body’s just not used to it.
>> Dr. Jeff Grimm: Right. It’s not — I think he explodes or something.
>> Jordan Baker: Right [laughing].
>> Dr. Jeff Grimm: Right.
>> Regina Barber DeGraaff: It’s a Monte Python scene.
>> Dr. Jeff Grimm: The Monte Python.
>> Regina Barber DeGraaff: Yeah [laughing].
[♪ Janelle Monae singing Wondaland ♪]
♪ Your magic mind ♪
♪ Makes love to mine ♪
♪ I think I’m in love, angel ♪
♪ Take me back to Wondaland ♪
♪ I gotta get back to Wondaland ♪
♪ Take me back to Wondaland ♪
♪ I think me left me underpants ♪
>> Regina Barber DeGraaff: I want to get to your research, though, because you’re saying you work with rats. So if you could give us like a brief “what do you do?” and then we’ll take a break and go right into your research.
>> Dr. Jeff Grimm: Into that. So, right, working with rats. And that started when I was in graduate school. I was actually working with rats, but looking at behavior related to antipsychotic drugs, not that the rats were psychotic.
>> Regina Barber DeGraaff: Are.
>> Dr. Jeff Grimm: But it was more the effects of drugs like antipsychotics, like some of the older ones like haloperidol and some of the newer ones like risperidone or Risperdal is the trade name.
>> Regina Barber DeGraaff: I don’t know any of these.
>> Dr. Jeff Grimm: And some of the effects they have on motor behavior like ability to move because antipsychotic drugs affect — some of them — predominately affect the neurotransmitter dopamine.
>> Regina Barber DeGraaff: OK.
>> Dr. Jeff Grimm: And dopamine is involved in reinforcement and all this addiction stuff. But it also — kind of as part of that — it’s involved in getting you to orient and be attracted to certain things in the environment. And that — to be able to do that, you have to be able to move.
So there’s this whole motor movement component and that’s what the new professor, at the time, that’s what he was studying.
>> Regina Barber DeGraaff: In grad school?
>> Dr. Jeff Grimm: Yeah. So then when I met him in grad school, he had just moved there from UCLA and he was like setting up to study the neurochemistry of the consequences of taking certain antipsychotic drugs, in particular over like months and months and months.
And so we were studying that, but he also was interested in drugs of abuse. So then, eventually, he got a grant and then we transitioned over to studying cocaine self-administration, primarily interested in that neurotransmitter — same neurotransmitter, dopamine.
>> Regina Barber DeGraaff: Right. And dopamine just like — can we give like a maybe easier definition? Like is it the stuff that makes you feel happy? Like is that basically what it is?
>> Dr. Jeff Grimm: It’s kind — now you’re sounding like that video.
>> Regina Barber DeGraaff: I know.
>> Dr. Jeff Grimm: I’m just kidding [laughing].
>> Regina Barber DeGraaff: The Kurzgesagt.
>> Jordan Baker: Crispy socks. I like that one.
>> Regina Barber DeGraaff: Kurzgesagt. So —
>> Dr. Jeff Grimm: So there’s this neurotransmitter. It’s actually not just in our brains, but it’s like in cardiovascular system. And so it’s involved in a lot of different kinds of functions in the body. But, in the brain — even within the brain, there’s several things going on. It’s involved in area of the brain like the hypothalamus, controlling — even like really strange things like body oil.
>> Regina Barber DeGraaff: Really? But, if you exercise, like does it come out? Like if you exercise, doesn’t that like trigger more happy happiness? What is that?
>> Dr. Jeff Grimm: To the happy thing, like how does it –? It seems to be involved in — along the spectrum of like hedonia, which is like feeling really good, and hedonics, that term — on the flip side is anhedonia, like the opposite of it.
>> Regina Barber DeGraaff: OK.
>> Dr. Jeff Grimm: So hedonic, like if you think of what people do, like engage in like the sky diving and like, wow, the rush of it and the feels and the yum of this or whatever, all the good stuff. On that — dopamine’s been associated with hedonia. Like it’s kind of the thrill seeking, the pleasure kind of stuff.
>> Regina Barber DeGraaff: Are.
>> Dr. Jeff Grimm: It’s — the reality of what’s going on in the brain during that — when somebody’s experiencing something like, “Wow, this is really great,” it’s really an interplay most likely between dopamine and other neurotransmitters including the endogenous opiates.
>> Regina Barber DeGraaff: OK.
>> Dr. Jeff Grimm: So we’re kind of back to —
>> Regina Barber DeGraaff: Back to the opiates.
>> Dr. Jeff Grimm: Those opiates are in there and when people expose — so it’s part of that, but it’s not just that. So that’s why I was kind of getting on your case about that.
>> Regina Barber DeGraaff: That’s right. Because it’s not as simplistic as the beautiful cartoons.
>> Jordan Baker: Right.
>> Dr. Jeff Grimm: Right. Or just like it’s the happy neurotransmitter.
>> Regina Barber DeGraaff: It’s the happy drug.
>> Dr. Jeff Grimm: Because it’s actually — it’s more of kind of a neuromodulator in some ways. Like it fine tunes how information is processed in the brain and can kind of push it in one direction versus another. It helps to make associations. So it’s very much involved in learning.
>> Regina Barber DeGraaff: Oh, wow.
>> Dr. Jeff Grimm: And that impulse control stuff. Attention. But, as we were talking about when the addiction definition through the DSM, you know, addiction’s a lot of things and it is. There’s the pleasure part of it, but there’s the impulse control and also getting caught up, like, “Oh, there’s that thing that reminds me,” the drug-paired cues, that kind of thing. So learning’s very important.
And so that’s why it keeps coming up I think. If you were to do a search online like in the scholarly stuff like PubMed like through the National Library of Medicine, and you do, “addiction neurotransmitter,” you’re going to see a lot of different neurotransmitters come up, but the bulk of that search, the thousands and thousands of papers, there’s going to be something about dopamine in there. And it’s going to be related to all these different pieces of the addiction definition we were talking about.
>> Regina Barber DeGraaff: We’re going to take a quick break and, when we come back, I want to talk about your research and then how addiction is portrayed in pop culture.
[♪ Janelle Monae singing Wondaland ♪]
♪ The music floats you gently on your toes ♪
♪ Touch the nose, he’ll change your clothes to tuxedos ♪
♪ Don’t freak and hide ♪
♪ I’ll be your secret Santa, do you mind? ♪
♪ Don’t resist ♪
♪ The fairygods will have a fit ♪
♪ We should dance ♪
♪ Dance in the trees ♪
♪ Paint mysteries ♪
♪ The magnificent droid plays there ♪
♪ Your magic mind ♪
♪ Makes love to mine ♪
♪ I think I’m in love, angel ♪
>> Regina Barber DeGraaff: Welcome back to Spark Science where we’re talking about addiction with Dr. Jeff Grimm. And we were just finishing up our discussion about that video we just watched. We did touch on one last thing and that was the idea of there’s the example in the video of Vietnam vets. And they come back home and they weren’t as addicted as people thought they would be. And it’s the idea of community and if these people who are addicted to cocaine or heroin, if they had a better community, then it would be easier for them to deal with the withdrawal.
So what do you have to say about that?
>> Dr. Jeff Grimm: Right. And, again, that’s — I remember being taught that in some — I don’t remember what class it was, but I mean that’s really common knowledge thing about Vietnam vets and there was that one big study where they followed people when they came back. And, for the most part, they did not continue with their heroin habits. And so I think that’s pretty interesting in itself, you know, trying to figure out exactly why that’s the case. The video, you know, suggests it’s because, when they came back, they had their social environment, the structure was there, support so they didn’t need to have the drug.
And maybe, for some people, that’s the case.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: It’s a little bit kind of over simplistic. And it also doesn’t really identify the fact that a lot of veterans, when they come back, you know, are experiencing stress, you know, post-traumatic stress disorder and — yeah. So there’s actually pretty high rates of substance use disorder among vets. And, you know, maybe that is a continuation of that same problem identified in the video, but not having the structure and all that.
So I’m not trying to diss that basic idea that’s there other than to say, like, well — you know — they just observed that that relationship between coming back and not, for the most part, continuing their heroin use. But you could come up with — it’s probably nuanced — the availability, it’s different, stressful — all this kind of stuff.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: So the part that — when I saw that in that video and then when you started talking about Dr. Alexander and the Rat Park and all that, where it intersects with what we’ve been doing in the lab here at Western for the last few years is that idea of an environment that provides something kind of unique. And I’ll use the psychology term “reinforcing” that could, for our subjects — and, again, our subjects are rats — provide an alternative kind of place that contrasts in some ways with the drug experience, in a way that having the nice environment makes the drug less reinforcing.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: So between the two. And so that kind of fits with, I think what Alexander was — he said it more in subsequent years, his first papers are pretty much straightforward laboratory reports.
>> Regina Barber DeGraaff: So this is the neuroscientist that is — the Rat Park –?
>> Dr. Jeff Grimm: Right. The Rat Park. So he’s written some books. If people are interested, just look up his name. And he was at Simon Fraser —
>> Regina Barber DeGraaff: Oh, that’s just right here.
>> Dr. Jeff Grimm: Yeah. Just right across the border. But he’s written some books more about the clinical experience of being an addict and that theme of connectedness and the social connections, all that kind of stuff. So there’s some cool stuff to look at there.
But, when you pull it back to the laboratory where you’re trying to like keep things all nice and your variables all controlled and all that kind of stuff — and if you’re working with rats too — I mean, like I said, they’re pretty smart, but they’re not, you know, Vietnam vets coming back. They don’t have this social network, you know, like we have and all the history and the comorbidity of other — smoking and all this kind of stuff.
So you can start to look at just kind of basic little elements that might be part of that big mess of being an addict.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: And so, in our lab, we have rats that self-administer, but we’re actually working —
>> Regina Barber DeGraaff: So how do they self-administer?
>> Dr. Jeff Grimm: Yeah. So how do they self-administer? It’s a little bit different than in the video. So the video just has bottle A and bottle B and they choose between the two.
>> Jordan Baker: But this one actually — get the rubber band out [laughing].
>> Dr. Jeff Grimm: This one — yeah. But what we’re doing right now is with sugar. So that’s a little bit different.
If you wanted to study intravenous drug use — that’s actually what I did study in graduate school and my postdoctoral work at NIH, so at the National Institute on Drug Abuse, which is part of NIH. In that case, they have a surgery and they have a catheter implanted into a jugular vein. And then you can set it up, after they’ve recovered from the surgery, where they make a response — like Skinner box, operant — you know, basically — have you heard of Skinner?
>> Jordan Baker: No.
>> Regina Barber DeGraaff: Neither of us. No.
>> Dr. Jeff Grimm: OK. So Skinner —
>> Jordan Baker: I know Principal Skinner.
>> Dr. Jeff Grimm: Principal Skinner — no.
>> Regina Barber DeGraaff: That’s not the one.
>> Dr. Jeff Grimm: This is a famous research psychologist. He’s often these days in the — psychology people are sometimes they’re like, “Oh,” that kind of stuff because people have moved into some other really important, interesting things.
>> Regina Barber DeGraaff: He’s not cool now.
>> Dr. Jeff Grimm: I think he’s still cool because he really —
>> Regina Barber DeGraaff: You’ve always thought it was cool.
>> Dr. Jeff Grimm: Yeah. He would do things to a small scale where you could operationalize a behavior, you could come up with a situation that was well-controlled. So basically it’s a rat in a box. There’s a lever. They press the lever.
>> Regina Barber DeGraaff: Oh, yes. OK.
>> Dr. Jeff Grimm: They get reinforced.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: So that word came from —
>> Regina Barber DeGraaff: Skinner.
>> Dr. Jeff Grimm: Well, he used it in that particular application and that became kind of synonymous with Skinner is all positive reinforcement versus negative reinforcement. That’s all Skinnerian psychology.
>> Jordan Baker: Skinnerian.
>> Dr. Jeff Grimm: Skinnerian! Right?
>> Regina Barber DeGraaff: Well, and that makes me think of Pavlovian. Right?
>> Dr. Jeff Grimm: Right. So Skinnerian is, you know, if you’re talking about the operant, it’s called the operant box. But the rat has to make some kind of response. So press the lever, they get reinforced. So that’s kind of Skinner in a nutshell.
>> Regina Barber DeGraaff: Kurzgesagt.
>> Dr. Jeff Grimm: So that’s skinner in a Kurzgesagt.
>> Regina Barber DeGraaff: Kurzgesagt
>> Dr. Jeff Grimm: Kurzgesagt?
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: Pavlov, and, of course, Kurzgesagt — German people are just like, “Oh, my god.”
So Pavlov’s like the dog. Pavlov’s dog. The intro psych kind of description — of course these studies are always more elaborate — the dog would be presented with — and they were restrained. They weren’t just like wondering around the lab, but like on a leash or something. Here’s some meat. And the dogs usually go like, “ooh,” you know?
>> Jordan Baker: How did that go?
>> Dr. Jeff Grimm: Bruugh. In Germany [laughing].
>> Jordan Baker: That’s their response to meat [laughing].
>> Regina Barber DeGraaff: They’re happy they see the meat.
>> Dr. Jeff Grimm: They salivate. They drool.
>> Jordan Baker: Right.
>> Dr. Jeff Grimm: Right? So that’s a normal response. You don’t have to learn. That just kind of happens.
And so what Pavlov did is he associated the meat presentation with a bell. Ring-a-ding. Over and over.
>> Regina Barber DeGraaff: Over and over and over.
>> Jordan Baker: The dinner bell.
>> Dr. Jeff Grimm: Dinner bell. Right. And then eventually you could ring the bell without the meat being present and the dog would salivate.
So that’s associative learning. And Pavlov — it’s sometimes referred to as Pavlovian associative learning or there’s other ways people describe it. So that’s probably happening in the Skinner box as well.
>> Regina Barber DeGraaff: When the rat’s going like, “murh.”
>> Dr. Jeff Grimm: Yeah. Because they’re associating like this place is where, when I press the lever, I get my heroin or my cocaine. Or — what we’re doing presently — my little drop of sucrose solution, which rats really do like sugar. They’re just like way into it.
>> Regina Barber DeGraaff: A lot of people like sugar.
>> Dr. Jeff Grimm: A lot of people like sugar. So that was something, when I was just finishing at my postdoc, that was at NIH, NIDA, which is in Baltimore. I didn’t mention that. So way on other side of the country. I was doing work with cocaine and we started doing a little bit of side stuff, kind of comparative side stuff with sugar. And then, when I came here to Western, I found it was easier to work with sugar partly because of the — not having to do as much surgical kind of stuff to get those catheters in, all that. But also — I’ve been here 14 plus years or something like that. It was starting to get to be that time where people start talking more and more about obesity.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: Especially in the United States. And there are some really interesting things. If you look at the Centers for Disease Control and Prevention, on their website they have these pictures. There’s a whole PowerPoint you can download. And they have maps of the United States. It looks like an election map because it’s color coded, but it’s by obesity rates.
And you can look over year by year by year and the colors change and change and change and it’s like — so that was — people were starting to pick up on that. And then I was like, “Well, we’re studying, you know, this behavior with the drugs where they come back over and over and then cues in the environment remind them.” You think of craving and not being able to kind of control your ability to refrain from something, if it’s a drug, but also a food.
So it was kind of like, “Is this similar or dissimilar to, you know, drug addictions?” So that question is part of what drove me the last many years now to study sugar. But in its own, it’s just become like an interesting thing to study partly because it’s linked to —
>> Regina Barber DeGraaff: Is the supply easier?
>> Dr. Jeff Grimm: Yeah. Does it apply more to obesity. And it’s kind of — you know, drug addiction stuff is a little bit more dramatic. Like heroin addicts. And it’s a huge problem. People are terribly suffering. And in some ways it’s getting worse like with heroin addiction. It’s not like there’s zillions more people doing it, but the rate is actually ticking up and overdoses are ticking up in the United States. It’s at a very low level, though, when you look at 30% of adults in the US are obese.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: And, you know, that’s like a lot of people. And it’s — there’s a lot of complications that arise from obesity.
>> Regina Barber DeGraaff: Well, I want to — I don’t want to let our viewers, our listeners down and I want to talk about pop culture.
>> Dr. Jeff Grimm: Right.
>> Regina Barber DeGraaff: Even if it is for a couple minutes.
>> Dr. Jeff Grimm: Yeah.
>> Regina Barber DeGraaff: So I want to —
>> Dr. Jeff Grimm: I’ve never — I don’t see movies ever.
>> Regina Barber DeGraaff: Ever? But you kids!
>> Dr. Jeff Grimm: I’m just kidding.
>> Regina Barber DeGraaff: Yeah. That’s a lie. I did want to bring up — which is going to make Jordan groan — and we have talked about this before, about that episode in Star Trek.
>> Jordan Baker: Groan.
>> Regina Barber DeGraaff: Yeah. The Star Trek Next Generation episode where they’re wearing those things that look like Google Glasses. And they’re playing that game. And I think they say —
>> Jordan Baker: Packman Go?
>> Regina Barber DeGraaff: No. Not Packman Go. I love Packman Go.
But so they’re wearing those Google Glasses in Star Trek Next Generation. It looks like Google Glasses. It’s not what that is. And they’re playing this game where, every time they, you know, score — score a point in the game, they get like, I think, dopamine or some sort of chemical release in their brain, which gives them happiness and like the whole ship becomes addicted except for like two children. And one of them is Ashley Judd actually, as a child. Like the actors.
>> Jordan Baker: No way.
>> Regina Barber DeGraaff: Yeah. Watch it. It’s Ashley Judd.
>> Jordan Baker: No, on won’t.
>> Regina Barber DeGraaff: You will.
>> Jordan Baker: On won’t watch it. No.
>> Regina Barber DeGraaff: It’s Ashley Judd and Wil Wheaton.
>> Dr. Jeff Grimm: I thought you liked Star Trek.
>> Regina Barber DeGraaff: No.
>> Jordan Baker: Well, yeah. No.
>> Regina Barber DeGraaff: OK. So like that’s really simplistic. I talked to you — they kind of think like — it would have to be more complicated than just, “I’m wearing these Google Glasses and getting chemicals,” or could it be that easy and people could just be like, “I’m going to do this forever?”
>> Dr. Jeff Grimm: So the idea of having some way to like stimulate the dopamine system, which is — it’s probably more complicated than that.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: And then that becoming like something you would be preoccupied with.
>> Regina Barber DeGraaff: And it’s part of the environment as well because the glasses affect your environment —
>> Dr. Jeff Grimm: Is that’s like taking it, you know, to this whole other level.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: But it’s been — it was shown in like I think the early 1950s in a couple of studies where they were looking for something else more related to depression, but, if you put an electrode down into the brain — they did that — it’s actually a video clip I show in some of my classes.
>> Regina Barber DeGraaff: Oh, please give us this video clip.
>> Dr. Jeff Grimm: They’ve — they put this electrode in. It was more for — again, for depression. Remember what I was saying like anhedonia and hedonia? So it’s like feeling really great versus like no feeling at all. You know? So you kind of think of like depression being somewhere along maybe on this end over here, like not really feeling things and blah.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: So they were trying to understand the neurobiology of that and also have this help somebody out. So they put this electrode into the area called the nucleus accumbens, which is a part of the brain that receives a lot of dopamine. So, again, if you did that literature search like “addiction, dopamine, brain region,” many, many, many hundreds if not thousands of the studies would be indicating nucleus accumbens. That’s the — one anatomical site that’s really key to this.
So, anyways, this person with the electrode was then supplied with a battery pack and a button. And she could push the button and it would, you know, add current into this electrode. And then she’d be like, “Hey.”
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: Yeah.
>> Regina Barber DeGraaff: So like —
>> Dr. Jeff Grimm: She really liked it.
>> Regina Barber DeGraaff: So like the Google Glasses in Star Trek Next Generation.
>> Dr. Jeff Grimm: And I don’t know what really happened with that person because I usually just — I just have this old video clip.
>> Regina Barber DeGraaff: Yeah. Maybe you should find out.
>> Dr. Jeff Grimm: So I don’t know if she later just become like, “Oh, just do that all the time.” But I could totally imagine if there was a way — I mean, there is a way if somebody wanted to consent to the surgery and have the elected implanted. Maybe can’t do it in the United States. Maybe Canada.
>> Jordan Baker: Why not. Couldn’t we sort of liken this to Packman where you’re going and you throw — I don’t know what they’re called, the poke ball or whatever.
>> Regina Barber DeGraaff: It’s called exactly that.
>> Jordan Baker: And then you catch it and then you get that dopamine, right?
>> Dr. Jeff Grimm: So you don’t need the electrode. If you could have some kind of — if it’s that enthralling.
>> Regina Barber DeGraaff: It is.
>> Dr. Jeff Grimm: And, yeah, there is — like you were saying, checking, becoming a habit, that kind of a thing, the DSM-V, which is the most recent one, has those substance use disorder criteria listed out, but internet gaming is one of the areas that became a new focus.
>> Regina Barber DeGraaff: Wow.
>> Dr. Jeff Grimm: And so, you know, now — that was before Packman Go and all that.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: But you could imagine like if you had the right circumstances and the right person, maybe it wouldn’t become like the Star Trek episode.
>> Regina Barber DeGraaff: Well, the video game addiction is happening a lot where there are these video game cafes, I believe, and there was — I think there was a problem in Korea or South Korea where they had these kids and they were like dying because they were playing for like 30 hours straight.
>> Dr. Jeff Grimm: Right. It has become — I was just looking at the DSM thing recently — but kind of at the bottom of it, like this is an area that needs to be further explored especially because we’re seeing things happening in Asian countries. It’s kind of like that’s where it seems to be most predominant now, but, you know, it could be — take off anywhere. People just get into it so much. But, yeah, people aren’t paying attention to their jobs and taking care — I read something about somebody not taking care of their kids and like crazy stuff like that.
>> Regina Barber DeGraaff: Yeah. But, on a hopeful end — I’d like to end on a hopeful note.
>> Jordan Baker: Sure.
>> Regina Barber DeGraaff: Yeah. So I think, on a hopeful note, you were saying that, as you’re studying addiction now even with sugar and all these things that we aren’t necessarily coining as, you know, the substance abuse — the drugs that we’re used to like heroin or cocaine, but like these video games and sugar, more and more research is being done for those things. And maybe the video isn’t — it’s kind of right.
>> Dr. Jeff Grimm: Well, and — yeah. The nice thing about it is that it does have like, “Here’s what we maybe could do about addiction.” You can’t go wrong by, you know, helping provide social support and structure for people. So I think that definitely is a key element of it. The video kind of like makes it sound like, you know, that’s it.
>> Regina Barber DeGraaff: Right.
>> Dr. Jeff Grimm: But if you have somebody who has had, you know, a long history of experience with heroin, or with cocaine, or maybe there’s something about sugar too, there are changes that happen throughout the brain. And they are related to, again, the ability to kind of learn about things, the reinforcement process that we were talking about, but also that impulse control. And those aren’t necessarily just going to go away.
I mean, talk about the brain being this plastic organ. The connections between things — it’s down to like — you know, you’re talking about trillions of connections between neurons. It’s trillions here. And you can’t just like go, “OK, now we’re in this nice environment and everything’s going to go back the way it was.” It’ll never go back the way it was. You’re going to have to kind of retrain the system and, for some people, that might be impossible especially in those parts of the brain involved in like impulse control. That might just always be an issue that you have to then kind of find work arounds. You have to learn other kinds of ways of managing that behavior.
So no matter the nicest place you end up in with the most amazing social support, you’re still dealing with, you know, somebody’s who’s potentially — your brain has changed.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: And that’s not going to be just simply fixed by a change in environment. But that would be a big piece of it. It’s like, “Well, let’s move you to this great place.” If, you know, like you think of the movie star people I sometimes horribly mention in my classes, like Robert Downey Jr.
>> Regina Barber DeGraaff: Right.
>> Jordan Baker: Sure.
>> Regina Barber DeGraaff: He’s doing great now.
>> Dr. Jeff Grimm: Doing so good. And, if people don’t know the history — and like he wasn’t always doing so well. And he relapsed I don’t know how many times. But he’s, you know, he’s in a place where it seems to be working out really well.
>> Regina Barber DeGraaff: Yeah.
>> Dr. Jeff Grimm: But, 20 years ago, he was like, “Op, he relapsed again. Great film, everything was — oh,” you know, that kind of a thing.
>> Regina Barber DeGraaff: Yeah.
>> Jordan Baker: So that’s sort of why they do all the rehab in these nice places, right? Everyone is really friendly and —
>> Dr. Jeff Grimm: Well, you provide — for some of those places, I think they do — especially if you can afford it. Unfortunately, that’s not the typical — that’s a whole other conversation [laughing].
>> Jordan Baker: Schick Shadel.
>> Regina Barber DeGraaff: I want to thank you for talking to us. And it is a little happiness because you’re saying, “You can work on this and I’m trying doing research and trying to find more things.”
>> Dr. Jeff Grimm: Right. And I’m obviously not the only — there’s a lot of people doing really great work. And not just in the United States.
[ Inaudible ]
[♪ Janelle Monae singing Wondaland ♪]
♪ I think I’m in love, angel ♪
♪ Take me back to Wondaland ♪
♪ I gotta get back to Wondaland ♪
♪ Take me back to Wondaland ♪
♪ I think me left me underpants ♪
>> Regina Barber DeGraaff: Thank you for listening to this episode of Spark Science about addiction and behavioral neuroscience. If there’s a science idea you’re curious about, please send us a message on either our Facebook or Twitter accounts. We are also available on Instagram and have a YouTube channel where we post special film shows. I’m Reginal Barber DeGraaff, Astrophysicist at Western Washington University. My cohost for this episode was Jordan Baker and our special guest was Dr. Jeff Grimm. Our theme son is “Chemical Calisthenics” by Blackalicious and our featured song is “Wondaland” by Janelle Monae.
In today’s show, we featured the addiction video from the YouTube channel Kurzgesagt. This show was recorded at Western Washington University. Our producer was Robert Clark and our editor was Nathan Miller. This show is entirely volunteer run and, if you’d like to help us out, please click the “donate” button at KMRE.org. All donations help to maintain our equipment and cover the expenses of special shows. Tune in next time for another episode of Spark Science.
[♪ Janelle Monae singing Wondaland ♪]
♪ Take me back to Wondaland ♪
♪ You know I love you, baby ♪
♪ Yes, I need you ♪
♪ I guess I want to know a love ♪
♪ Take me back, I want to stay the night ♪
♪ I’m so inspired, baby ♪
♪ My supernova shining bright ♪
♪ Hallelujah ♪
♪ Hallelujah ♪
[♪Blackalicious rapping Chemical Calisthenics ♪]
♪ Lead, gold, tin, iron, platinum, zinc, when I rap you think ♪
♪ Iodine nitrate activate ♪
♪ Red geranium, the only difference is I transmit sound ♪
♪ Balance was unbalanced then you add a little talent in ♪
♪ Careful, careful with those ingredients ♪
♪ They could explode and blow up if you drop them ♪
♪ And they hit the ground ♪
[End of podcast.]